Home Pictures/Films Publications People Current Research




Selected Publications


  1. Lin Yang, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DM, Thomas SM and Luscinskas FW. Endothelial cell cortactin coordinates ICAM-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J. Immunol., 2006, In press.

  2. Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM. Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15;114(7):681-7. Epub 2006 Aug 7.

  3. Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 2006 Jun 1;176(11):6568-75.

  4. Xie C, Alcaide P, Geisbrecht BV, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T. Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006 Apr 17;203(4):985-94. Epub 2006 Apr 3.

  5. Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK. Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res. 2006 May 12;98(9):1134-40. Epub 2006 Mar 30.

  6. Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM. Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 7;113(5):691-700.

  7. Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW. Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res. 2006 Feb 17;98(3):394-402. Epub 2005 Dec 29.
  8. Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005 Nov 15;106(10):3432-9. Epub 2005 Jul 12.
  9. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood. 2005 Jul 15;106(2):584-92. Epub 2005 Apr 5.

  10. Rao RM, Shaw SK, Kim M, Luscinskas FW. Emerging topics in the regulation of leukocyte transendothelial migration. Microcirculation. 2005 Jan-Feb;12(1):83-9. Review.

  11. Shaw SK, Ma S, Kim MB, Rao RM, Hartman CU, Froio RM, Yang L, Jones T, Liu Y, Nusrat A, Parkos CA, Luscinskas FW. Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med. 2004 Dec 20;200(12):1571-80.

  12. Rao RM, Betz TV, Lamont DJ, Kim MB, Shaw SK, Froio RM, Baleux F, Arenzana-Seisdedos F, Alon R, Luscinskas FW. Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration. J Exp Med. 2004 Sep 20;200(6):713-24.

  13. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 1;105(5):1950-5. Epub 2004 Sep 16.

  14. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, Garcia-Cardena G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17;199(10):1305-15. Epub 2004 May 10.

  15. Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15;103(8):3013-9. Epub 2003 Dec 18.

  16. Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas FW, Lopez J, Plow E, Simon DI. Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003 Oct 6;198(7):1077-88.

  17. Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med. 2003 Jun 16;197(12):1701-7.
  18. Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA Jr, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May;162(5):1591-601.

  19. Grabie N, Delfs MW, Lim YC, Westrich JR, Luscinskas FW, Lichtman AH. Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Eur J Immunol. 2002 Oct;32(10):2766-72.
  20. Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D and Luscinskas FW. Neutrophil Elastase or MMP-9 are not Essential for Murine Neutrophil Transendothelial Migration in vitro. J Leukoc Biol. 2002 May;71(5):821-8.

  21. Boyce JA, Mellor EA, Perkins B, Lim YC, and Luscinskas FW. Human mast cell progenitors use  4-integrin -VCAM-1 and PSGL-1 - E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15;99(8):2890-6.

  22. Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW. Reduced Expression of JAM and PECAM-1 in Human Vascular Endothelium by TNF-alpha plus INF-gamma Does Not Reduce Leukocyte Transmigration Under Flow Conditions. Am. J. Path. 2001; 159:2281-2291.

  23. Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH and Luscinskas FW. IL-12, STAT4 dependent upregulation of naive T cell core 2 beta-1,6-N-acetylglucosaminyltransferase (G2GnT), an enzyme essential for expression of functional selectin ligands. J. Immunol. 2001; 167:4476-4484.

  24. Shaw SK, Bamba, PS, Perkins, BN, Luscinskas FW. Real-time imaging of vascular endothelial VE-cadherin during leukocyte transmigration across endothelium. J. Immunol. 2001;167:2323-2330.

  25. Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun;14(6):693-704.

  26. Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell S-E, Aiello LP, Luscinskas FW, Adamis AP. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Assoc. Res. Vis. Opth. 2000; 41:1153-1158.

  27. Lim YC, Wakelin MW, Henault L, Goetz DJ, Yednock T, Cabanas C, Sanchez-Madrid F, Lichtman AH, Luscinskas FW. Alpha4beta1-integrin activation correlates with high efficiency of CD4+ T cell adhesion to VCAM-1 under flow. Microcirculation. 2000; 7:201-214.

  28. Allport JR, Muller WA, Luscinskas FW. Monocytes induce reversible focal changes in VE-cadherin complex during transendothelial migration under flow. J. Cell. Biol. 2000; 148:203-216.

  29. Xie H, Lim YC,Luscinskas FW, Lichtman AH. Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. J Exp Med. 1999. 189:1765-76.

  30. Tan P, Luscinskas FW, Homer-Vanniasinkam S. Cellular and molecular mechanisms of inflammation and thrombosis. Eur J Vasc Endovasc Surg. 1999.  17:373-89. 

  31. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, Rosenzweig A. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999.  398:718-23.

  32. Montoya MC, Holtmann K, Snapp KR, Borges E, Sanchez-Madrid F, Luscinskas FW, Kansas G, Vestweber D, de Landazuri MO. Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand. J Clin Invest. 1999. 103:1317-27.

  33. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol. 1999. 162:3193-201.

  34. Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF. The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J Exp Med. 1999. 189:241-52.