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Luscinskas Laboratory

Vascular Biology Research


The vascular endothelium forms a thin, continuous monolayer that lines the cardiovascular system and thus, is positioned strategically at the interface between flowing blood and the bodyís underlying tissues and organs. By virtue of this anatomical location, the vascular endothelium plays a critical role in regulating the blood vessel wall in normal and pathophysiological settings such as inflammatory and immune responses.  It is now well appreciated that the endothelium is not just a passive barrier, but in fact, a large multifunctional organ that actively participates in many critical processes including inflammation and response to injury, selective barrier function, vascular tone by producing vasoconstricting and vasorelaxing substances, hemostatic functions, chronic vascular remodeling, extracellular matrix and transduction of biomechanical forces, to name a few.

The Luscinskas labís focus is to understand endothelial dependent mechanisms in recruitment of chronic inflammatory leukocytes to sites of inflammatory and immune reactions.


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Vascular Research Division
Brigham and Women's Hospital
The Luscinskas Laboratory
NRB - Room 752
77 Avenue Louis Pasteur
Boston MA. 02115

tel:  (617) 525-4337
fax: (617) 525-4333

email : fluscinskas@rics.bwh.harvard.edu



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